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Desvenlafaxine is a newly available serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant 1 that has been shown to be an effective and safe treatment for major depressive disorder (MDD) in adults.

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Because of potentially lethal dietary and drug interactions, inhibitors have historically been reserved as a last line of treatment, used only when other classes of antidepressant drugs (for example and ) have failed.

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