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Although it may seem strange, the situation isn't specific to escitalopram, a member of a class of antidepressants that also includes fluoxetine (Prozac), sertraline (Zoloft), and citalopram (Celexa), along with their generic equivalents.
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Because of its long half-life, patients should allow at least five weeks between discontinuation of fluoxetine and commencement of mono-amine oxidase inhibitor (MAOI) therapy.
The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees.
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While physical dependence and withdrawal occur with some drugs of abuse (opiates, ethanol), these phenomena are not useful in the diagnosis of addiction because they do not occur with other drugs of abuse (cocaine, amphetamine) and can occur with many drugs that are not abused (propranolol, clonidine).
L'escitalopram est le plus sélectif des antidépresseurs parmi les inhibiteurs spécifiques du recaptage de la sérotonine (ISRS).
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Therefore, when compared with paroxetine and sertraline, escitalopram as an ASRI different from classical SSRIs consistently shows advantages in efficacy and tolerability profiles, and nonclinical data have offered possible mechanisms through which escitalopram could be more efficacious based on its interaction with orthosteric and allosteric binding sites at the SERT.
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For SSRIs, a relatively homogenous drug class, differences among the pharmacokinetic properties such as elimination half-life and metabolism may be the most clinically relevant ().
Thus, although venlafaxine may be more efficacious than most SSRIs, the proposed mechanism of action of escitalopram may explain why it is as efficacious as venlafaxine, with the superior tolerability of an SSRI.
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