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Risk of suicidality; importance of patients, family, and caregivers being alert to and immediately reporting emergence of suicidality, worsening depression, manic or hypomanic symptoms, irritability, agitation, or unusual changes in behavior, especially during the first few months of therapy or during periods of dosage adjustment.
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However, those features may simply indicate the higher usage of potent neuroleptics in this population.
The Cochrane Database of Systematic Reviews (2): CD001162.
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These trends were replicated in the remission rates (difference of 13% in patients whose symptoms worsened and 12.
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Prescribing Information for Abilify (Aripiprazole): What is Abilify?
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NMS often occurs shortly after the initiation of neuroleptic treatment, or after dose increases.
Careful consideration of the NNT and NNH for each AA can enable clinicians to practically weigh the benefit versus risk ratio and may help to select the best available AA in clinical practice.
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Previous antipsychotic therapy was reduced biweekly by 25%.
Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy with ABILIFY.
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Neuroleptic malignant syndrome (NMS) is a rare, but life-threatening, idiosyncratic reaction to neuroleptic medications that is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction.
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Elderly patients with major depressive disorder (MDD) who score well on a test that measures the ability to shift attention between tasks may be more likely to respond to augmentation with aripiprazole after failing to respond to first-line therapy with venlafaxine, according to a published yesterday in JAMA Psychiatry.
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In summary, aripiprazole resulted in an effective treatment for TD, but it was only moderately effective on co-occurring ADHD symptomatology.
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Limited justification exists to beam decisions per that patients will advantage from that second-line treatments, a authors note.
While the ABLLS-R is most commonly used on children with developmental disabilities and delays (including ), it can be used for anyone who may be lacking in basic communication or life skills.
For some patients with MDD who do not obtain adequate symptom relief with antidepressant monotherapy, adjunctive therapies can significantly improve depressive symptoms.
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The most widely accepted mechanism by which antipsychotics cause neuroleptic malignant syndrome is that of dopamine D2 receptor antagonism.
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In one study, aripiprazole was used to treat 10 elderly hospitalized patients between 62 and 85 years of age who manifested signs of psychosis related to schizophrenia or schizoaffective disorder.
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Table 6 shows the proportion of adolescents with schizophrenia (13 to 17 years) and pediatric patients with bipolar disorder (10 to 17 years) with changes in total cholesterol and HDL cholesterol (pooled from two placebo-controlled trials; median exposure 42 to 43 days) and fasting triglycerides (pooled from two placebo-controlled trials; median exposure 42 to 44 days).
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Clearly, additional randomized double-blind, placebo-controlled trials are needed, particularly in adults with ASDs.
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