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Next time, do I leave my pump on for the tests and, what are your overall impressions about the possibility of LADA given the low insulin needs and the quickness of becoming insulin dependent.

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In the Diabetes Prevention Program (DPP) trial, diet and exercise alone decreased the rate of onset of diabetes mellitus by 58% after 3 years.

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It's not branded the way the newer analog insulins are.

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The maximum dose of gliclazide (regular formulation) between studies varied from 240 to 320 mg.

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The insulin treatment for type 1 diabetes is available in several forms including long-acting, short-acting and rapid-acting therapies.

Drink plenty of fluids while taking this medication unless your doctor tells you otherwise.

When the number of people who developed diabetes during the three month "washout" phase during which the drug was discontinued was included in the study results, a further 15.

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During follow-up, 392 patients left their dialysis center for reasons other than death, including 194 who received a transplant (95 in the standard-dose group and 99 in the high-dose group; 93 in the low-flux group and 101 in the high-flux group) and 198 others who switched methods of dialysis or transferred to nonparticipating facilities.

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Meier JJ, Baller B, Menge BA, Gallwitz B, Schmidt WE, Nauck MA: Excess glycaemic excursions after an oral glucose tolerance test compared with a mixed meal challenge and self-measured home glucose profiles: is the OGTT a valid predictor of postprandial hyperglycaemia and vice versa?

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ULN, and greater than 3 times the ULN occurred in 14%, 6%, and 3%, respectively, of acarbose-treated patients as compared to 7%, 2%, and 1%, respectively, of placebo-treated patients.

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Ask your health care provider if acarbose may interact with other medicines that you take.

ACE Consensus Panel on type-2 diabetes mellitus moves sulfonylureas to a lower priority in dual-combination or triple-combination drug selection because of the potential for hypoglycemia, weight gain, and inability to maintain glycemic control after approximately 1 to 2 years in most patients.

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EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome.

Eye exam: Diabetics should have their eyes checked by an ophthalmologist (eye specialist) each year for retinopathy, glaucoma and cataracts.

Acarbose is approved for treatment of IGT in 25 countries.

Adverse reactions include weight gain and hypoglycemia.

Acarbose does not produce hypoglycemia; however, hypoglycemia may develop if used together with sulfonylureas or insulin.

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In a one-year safety study, during which patients kept diaries of gastrointestinal symptoms, abdominal pain and diarrhea tended to return to pretreatment levels over time, and the frequency and intensity of flatulence tended to abate with time.

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Inhaled insulin claimed to have similar efficacy to injected insulin, both in terms of controlling glucose levels and blood half-life.

In view of its usually acceptable level of side effects that are, if they occur, mostly limited to transient gastrointestinal symptoms, acarbose could well be a strong future player in CV disease secondary prevention.

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Research is ongoing to determine the mechanisms by which acarbose provides cardiovascular benefits, but it seems clear that the benefits can be attributed, at least in part, to the fact that acarbose directly targets postprandial hyperglycaemia, which limits endothelial damage and reduces the risk of macrovascular complications.

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Other inclusion criteria such as metabolic parameters or concomitant antidiabetic medication varied according to the primary objective of the different studies.

Current discouraging results from many trials of antidiabetic medications to significantly lower CV event rates in diabetic patients, should only draw further attention on alternative glucose lowering agents, among which acarbose is indeed promising.

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Yang W, Liu J, Shan Z, Tian H, Zhou Z, Ji Q, Weng J, Jia W, Lu J, Xu Y, Yang Z, Chen W: Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial.

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Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems.

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