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Patients with NERD may exhibit similar symptom severity to those with erosive GERD but as many as half of them may have a normal esophageal pH testing demonstrating pH values within the normal range of healthy subjects ().
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NOTES: Do not share this medication with others.
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Except for diarrhea, the adverse effects of PPIs do not appear to be related to age, dosage, or duration of treatment.
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Compiled data from 3556 patients taking rabeprazole for up to one year demonstrated that the most common adverse effect was headache with an incidence (2.
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H2-receptor antagonists, prostaglandin or sucralfate within 14 days prior to enrollment or with a proton pump inhibitor, prokinetic agent or bismuth subsalicylate within 30 days prior to enrollment; concurrent significant illnesses including cancer and renal or hepatic disease; any history of clinically significant alcohol abuse or other psychiatric illnesses; any predisposing condition that might interfere with the absorption, distribution, metabolism or excretion of any study drug; any history of multiple medication allergies or history of severe drug-associated adverse event.
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Oral rabeprazole also maintained an overall greater median pH on day 1 of dosing over the nocturnal hours as compared to pantoprazole ().
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The other is an ongoing 10-year study, in which maintenance therapy with pantoprazole 40 mg to 160 mg daily was well tolerated in patients with healed peptic ulcers or erosive esophagitis.
Once-daily treatment with Pantoprazole 40 mg or 20 mg resulted in significantly superior rates of healing at both 4 and 8 weeks compared with twice-daily treatment with 150 mg of nizatidine.
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Initiation of empiric therapy with acid suppressive therapy, usually a PPI, in patients with symptoms consistent with GERD is an efficient and acceptable method to confirm GERD; this method lacks specificity ().
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Suppression of gastric acid by PPIs interrupts negative-feedback mechanisms by which gastrin secretion is regulated, since high levels of gastric acid normally inhibit gastrin secretion, prolonged PPI treatment leads to hypergastrinemia.
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HRQoL was assessed using 4 domains of the SF-36, the SF-12 summary scales and the gastrointestinal system rating scale (GSRS).
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